Toxicological assessment

This service is a scientific risk evaluation, not a generic bundle of product tests. The assessor reviews the complete composition, ingredient toxicology and expected consumer exposure to determine whether the proposed use is supported by the available evidence.

Hazard and exposure review

• Ingredient identity, concentration and relevant impurities
• Local effects such as irritation and sensitization
• Systemic toxicity information and routes of exposure
• Dermal absorption assumptions or measured data where relevant
• Use frequency, application amount, product type and intended users

Existing studies, justified read-across or suitable modeling may contribute to the assessment. Margins of safety can be calculated where the data and endpoint support them. Data gaps and uncertainty should be stated rather than hidden by a blanket safe-product conclusion.

Contribution to the safety dossier

Product stability, microbiological quality, preservation and packaging information provide context for the toxicological evaluation. New tests should be selected to answer identified gaps, not presented as automatically required for every formula.

In the EU, the assessment contributes to the Cosmetic Product Safety Report within the Product Information File and must meet the applicable assessor-qualification requirements. Other markets have their own safety-substantiation expectations. The report should define the intended use, supporting rationale and any conditions or limitations, without promising that no consumer can experience an adverse reaction.