---
title: "AMP production"
description: "Measure endogenous antimicrobial peptide production in skin models."
image: "https://cosmetic-labs.com/wp-content/uploads/antimicrobial-peptides-service-1200x1200-1.webp"
---
# AMP production

> Measure endogenous antimicrobial peptide production in skin models.

Source: https://cosmetic-labs.com/services/clinical/efficacy/skin-comfort-testing/inflammation-skin-immunity/antimicrobial-peptides
Created: 2025-04-27T10:54:31+00:00
Modified: 2026-10-25T10:06:00+00:00
Author: Emilie SCHOL

AMP production | Cosmetic Labs

## What is AMP production?

AMP production testing measures how cosmetic ingredients affect endogenous antimicrobial peptide production in skin models. Gene expression, peptide levels, and suitable functional assays help investigate innate defense responses without assuming that increased production is always beneficial.

### Why do you need this service?
AMP production studies investigate whether an ingredient changes endogenous antimicrobial peptide responses in skin models. Interpret peptide expression or abundance alongside viability and, where relevant, a separately measured functional response.

## Be the first company on this service page

No published company profiles are linked to AMP production or its more specific services yet. Explore the service categories or add an explicitly supported capability to your company profile.

[List your company](https://cosmetic-labs.com/account/companies/new)
Definition
## AMP production
Antimicrobial peptides are components of the skin’s innate defense system. In this testing service, AMP production refers to the response of skin cells to an ingredient or formulation, rather than the commercial synthesis of peptide raw materials.

### Measuring the skin-model response
Labs use keratinocyte cultures or reconstructed skin models to examine changes after treatment and, where relevant, a defined challenge. The selected peptide family and model determine the measurements.

Expression of genes encoding antimicrobial peptides
- Peptide concentrations in cells or culture medium
- Concentration- and time-dependent responses
- Cell viability and inflammatory markers alongside AMP measurements
Expression data and protein measurements address different stages of production and should not be treated as equivalent.

### Functional testing and controls
Where the research question requires it, functional assays can investigate antimicrobial activity against selected organisms. Purified or synthesized reference peptides may serve as controls, but making them is an assay-support activity rather than the core service.

Reports should explain whether treatment changed peptide expression, measured peptide abundance, or functional activity. These findings can support research into skin defense, but do not prove infection prevention, broad pathogen protection, or improved barrier function without additional evidence.

Applications
## Investigating host antimicrobial peptide responses
Choose measurements that distinguish a change in transcript expression from a change in peptide abundance or activity. A defined challenge can be included where it fits the research question and model. Synthesizing an antimicrobial peptide is a different service from measuring the model’s own peptide production.

Changes in cytokines can provide context but do not substitute for the AMP endpoint. Increased peptide levels are not automatically beneficial, and lower signals can reflect toxicity or model limitations. The report should identify which peptides and responses were assessed.

These studies can inform innate-defence research and formulation development. They do not establish broad pathogen protection, finished-product preservation or a clinical skin-barrier benefit. Any microbial inhibition or human-use outcome needs suitable supporting evidence.

ExplorationLearn more about Inflammation & Skin ImmunityInvestigate skin inflammation and innate immune responses through cytokines, signalling pathways and cell assays suited to the research question. Explore another Inflammation & Skin Immunity page on cosmetic-labs.com.

#### [Sensitive skin and skin comfort efficacy testing](https://cosmetic-labs.com/services/clinical/efficacy/skin-comfort-testing/inflammation-skin-immunity/sensitive-skin)
Investigate sensitive-skin mechanisms through TRPV activity, substance P signalling and neurogenic response assays in suitable laboratory models. [Check this service](https://cosmetic-labs.com/services/clinical/efficacy/skin-comfort-testing/inflammation-skin-immunity/sensitive-skin)
#### [TRPV receptors modulation](https://cosmetic-labs.com/services/clinical/efficacy/skin-comfort-testing/inflammation-skin-immunity/trpv-receptors)
TRPV receptor assays measure channel activity and cellular responses to compare cosmetic actives and investigate possible soothing mechanisms. [Check this service](https://cosmetic-labs.com/services/clinical/efficacy/skin-comfort-testing/inflammation-skin-immunity/trpv-receptors)
#### [Substance P regulation](https://cosmetic-labs.com/services/clinical/efficacy/skin-comfort-testing/inflammation-skin-immunity/substance-p)
Investigate how cosmetic ingredients affect substance P release or signalling in relevant models, with findings limited to the tested skin mechanism. [Check this service](https://cosmetic-labs.com/services/clinical/efficacy/skin-comfort-testing/inflammation-skin-immunity/substance-p)
#### [Neurogenic reduction](https://cosmetic-labs.com/services/clinical/efficacy/skin-comfort-testing/inflammation-skin-immunity/neurogenic-inflammation)
Neurogenic reduction studies measure nerve-mediated inflammatory signals in relevant models to investigate mechanisms for soothing cosmetics. [Check this service](https://cosmetic-labs.com/services/clinical/efficacy/skin-comfort-testing/inflammation-skin-immunity/neurogenic-inflammation)
#### [Skin immunity efficacy testing](https://cosmetic-labs.com/services/clinical/efficacy/skin-comfort-testing/inflammation-skin-immunity/skin-immunity)
Skin immunity testing examines receptor signals, antimicrobial peptides and immune-cell responses to investigate cosmetic ingredient activity. [Check this service](https://cosmetic-labs.com/services/clinical/efficacy/skin-comfort-testing/inflammation-skin-immunity/skin-immunity)
#### [Innate response activation](https://cosmetic-labs.com/services/clinical/efficacy/skin-comfort-testing/inflammation-skin-immunity/innate-immunity)
Innate response assays examine receptor signaling, cytokines and stress markers to assess ingredient-driven activation in skin or immune cells. [Check this service](https://cosmetic-labs.com/services/clinical/efficacy/skin-comfort-testing/inflammation-skin-immunity/innate-immunity)
#### [TLR modulation](https://cosmetic-labs.com/services/clinical/efficacy/skin-comfort-testing/inflammation-skin-immunity/toll-receptor)
TLR modulation testing measures receptor-specific signaling and cytokine responses to investigate cosmetic ingredient effects on immune pathways. [Check this service](https://cosmetic-labs.com/services/clinical/efficacy/skin-comfort-testing/inflammation-skin-immunity/toll-receptor)
#### [Dendritic cell function](https://cosmetic-labs.com/services/clinical/efficacy/skin-comfort-testing/inflammation-skin-immunity/dendritic-cell)
Dendritic cell assays measure activation markers, cytokines and viability to investigate cosmetic ingredient effects on immune-cell function. [Check this service](https://cosmetic-labs.com/services/clinical/efficacy/skin-comfort-testing/inflammation-skin-immunity/dendritic-cell)
#### [β-defensin expression](https://cosmetic-labs.com/services/clinical/efficacy/skin-comfort-testing/inflammation-skin-immunity/beta-defensin)
Beta-defensin expression testing measures transcripts and peptide levels in skin models to investigate ingredient effects on defense signaling. [Check this service](https://cosmetic-labs.com/services/clinical/efficacy/skin-comfort-testing/inflammation-skin-immunity/beta-defensin)
#### [Skin Inflammation Mechanism Studies](https://cosmetic-labs.com/services/clinical/efficacy/skin-comfort-testing/inflammation-skin-immunity/inflammatory-disorders)
Investigate skin inflammatory mechanisms through cytokines, signalling pathways and cell responses in defined models for soothing-product research. [Check this service](https://cosmetic-labs.com/services/clinical/efficacy/skin-comfort-testing/inflammation-skin-immunity/inflammatory-disorders)
#### [Cytokine profile modulation](https://cosmetic-labs.com/services/clinical/efficacy/skin-comfort-testing/inflammation-skin-immunity/cytokine-profile)
Cytokine profiling compares signaling mediators in cell or tissue models to investigate ingredient responses and guide sensitive-skin research. [Check this service](https://cosmetic-labs.com/services/clinical/efficacy/skin-comfort-testing/inflammation-skin-immunity/cytokine-profile)
#### [Cytokine cascade modulation](https://cosmetic-labs.com/services/clinical/efficacy/skin-comfort-testing/inflammation-skin-immunity/inflammatory-cascade)
Measure ingredient effects on inflammatory cascades in skin-cell or tissue models exposed to a defined challenge, including UV where relevant. [Check this service](https://cosmetic-labs.com/services/clinical/efficacy/skin-comfort-testing/inflammation-skin-immunity/inflammatory-cascade)
#### [NF-κB pathway inhibition](https://cosmetic-labs.com/services/clinical/efficacy/skin-comfort-testing/inflammation-skin-immunity/nfkb-inhibition)
Assess ingredient effects on NF-κB activation and downstream inflammatory gene expression in cell models relevant to soothing-formulation research. [Check this service](https://cosmetic-labs.com/services/clinical/efficacy/skin-comfort-testing/inflammation-skin-immunity/nfkb-inhibition)
#### [TNF-α/IL-6 suppression](https://cosmetic-labs.com/services/clinical/efficacy/skin-comfort-testing/inflammation-skin-immunity/cytokines-reduction)
Measure TNF-α and IL-6 responses in defined skin or immune-cell models, interpreting protein and transcript results alongside cell viability controls. [Check this service](https://cosmetic-labs.com/services/clinical/efficacy/skin-comfort-testing/inflammation-skin-immunity/cytokines-reduction)
#### [Anti-inflammatory mediators increase testing](https://cosmetic-labs.com/services/clinical/efficacy/skin-comfort-testing/inflammation-skin-immunity/anti-inflammatory)
Investigate ingredient effects on inflammation-limiting mediators such as IL-10, using regulatory endpoints suited to the selected laboratory model. [Check this service](https://cosmetic-labs.com/services/clinical/efficacy/skin-comfort-testing/inflammation-skin-immunity/anti-inflammatory)
#### [Eicosanoid mediator control](https://cosmetic-labs.com/services/clinical/efficacy/skin-comfort-testing/inflammation-skin-immunity/inflammatory-mediators)
Investigate ingredient effects on prostaglandins and leukotrienes using enzyme or cell assays, with findings scoped to inflammatory signalling pathways. [Check this service](https://cosmetic-labs.com/services/clinical/efficacy/skin-comfort-testing/inflammation-skin-immunity/inflammatory-mediators)
#### [COX-2 inhibition](https://cosmetic-labs.com/services/clinical/efficacy/skin-comfort-testing/inflammation-skin-immunity/cox2)
Measure COX-2 inhibition and related prostaglandin responses with enzyme or cell assays to investigate inflammatory mechanisms in cosmetic research. [Check this service](https://cosmetic-labs.com/services/clinical/efficacy/skin-comfort-testing/inflammation-skin-immunity/cox2)
#### [Prostaglandin synthesis regulation](https://cosmetic-labs.com/services/clinical/efficacy/skin-comfort-testing/inflammation-skin-immunity/prostaglandin)
Investigate prostaglandin synthesis and regulation in laboratory models to assess ingredient effects on inflammatory pathways relevant to skin comfort. [Check this service](https://cosmetic-labs.com/services/clinical/efficacy/skin-comfort-testing/inflammation-skin-immunity/prostaglandin)
#### [Mast cell stabilization](https://cosmetic-labs.com/services/clinical/efficacy/skin-comfort-testing/inflammation-skin-immunity/mast-cell)
Assess mast-cell activation and degranulation through histamine release and related markers in laboratory models relevant to reactive-skin research. [Check this service](https://cosmetic-labs.com/services/clinical/efficacy/skin-comfort-testing/inflammation-skin-immunity/mast-cell)
#### [Inflammaging](https://cosmetic-labs.com/services/clinical/efficacy/skin-comfort-testing/inflammation-skin-immunity/inflammaging)
Investigate persistent, low-grade inflammatory responses associated with skin ageing through cytokine, stress and senescence markers in defined models. [Check this service](https://cosmetic-labs.com/services/clinical/efficacy/skin-comfort-testing/inflammation-skin-immunity/inflammaging)

Continue with

[Google](https://cosmetic-labs.com/?lean_auth=start&provider=google&redirect_to=https://cosmetic-labs.com/&error_return=https://cosmetic-labs.com/services/clinical/efficacy/skin-comfort-testing/inflammation-skin-immunity/antimicrobial-peptides)
[LinkedIn](https://cosmetic-labs.com/?lean_auth=start&provider=linkedin&redirect_to=https://cosmetic-labs.com/&error_return=https://cosmetic-labs.com/services/clinical/efficacy/skin-comfort-testing/inflammation-skin-immunity/antimicrobial-peptides)

What does “Verified” mean?
Verified means the claimant’s company affiliation was checked.

Something not right?Let us know if any information on this page is incorrect or if you have concerns about who manages it.

[Report an issue](https://cosmetic-labs.com/platform/contact)

© 2026 Cosmetic Labs. All rights reserved.

---

## Site identity

- Organization: Cosmetic Labs
- Description: Cosmetic Labs is a directory and a platform to meet all your cosmetic product development needs. From sourcing raw material to finding the best CRO for your needs.
- Website: https://cosmetic-labs.com

```json
[{"@type":"WebPage","name":"AMP production","url":"https:\/\/cosmetic-labs.com\/services\/clinical\/efficacy\/skin-comfort-testing\/inflammation-skin-immunity\/antimicrobial-peptides","mainEntity":{"@id":"https:\/\/cosmetic-labs.com\/services\/clinical\/efficacy\/skin-comfort-testing\/inflammation-skin-immunity\/antimicrobial-peptides#service"},"isPartOf":{"@id":"https:\/\/cosmetic-labs.com\/services\/clinical\/efficacy\/skin-comfort-testing\/inflammation-skin-immunity#webpage"},"breadcrumb":{"@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/cosmetic-labs.com\/"},{"@type":"ListItem","position":2,"name":"Services","item":"https:\/\/cosmetic-labs.com\/services"},{"@type":"ListItem","position":3,"name":"Efficacy & Claims","item":"https:\/\/cosmetic-labs.com\/services\/clinical"},{"@type":"ListItem","position":4,"name":"Cosmetic Efficacy Testing","item":"https:\/\/cosmetic-labs.com\/services\/clinical\/efficacy"},{"@type":"ListItem","position":5,"name":"Skin Comfort Testing","item":"https:\/\/cosmetic-labs.com\/services\/clinical\/efficacy\/skin-comfort-testing"},{"@type":"ListItem","position":6,"name":"Inflammation & Skin Immunity","item":"https:\/\/cosmetic-labs.com\/services\/clinical\/efficacy\/skin-comfort-testing\/inflammation-skin-immunity"},{"@type":"ListItem","position":7,"name":"AMP production","item":"https:\/\/cosmetic-labs.com\/services\/clinical\/efficacy\/skin-comfort-testing\/inflammation-skin-immunity\/antimicrobial-peptides"}]},"inLanguage":"en-US","@id":"https:\/\/cosmetic-labs.com\/services\/clinical\/efficacy\/skin-comfort-testing\/inflammation-skin-immunity\/antimicrobial-peptides#webpage"},{"@type":"Service","name":"AMP production","url":"https:\/\/cosmetic-labs.com\/services\/clinical\/efficacy\/skin-comfort-testing\/inflammation-skin-immunity\/antimicrobial-peptides","mainEntityOfPage":{"@id":"https:\/\/cosmetic-labs.com\/services\/clinical\/efficacy\/skin-comfort-testing\/inflammation-skin-immunity\/antimicrobial-peptides#webpage"},"description":"Measure endogenous antimicrobial peptide production in skin models.","image":{"@type":"ImageObject","url":"https:\/\/cosmetic-labs.com\/wp-content\/uploads\/antimicrobial-peptides-service-1200x1200-1-1024x1024.webp","width":1024,"height":1024,"caption":"A gloved hand holds a short cartridge over opened packaging beside capped vials and a closed culture flask."},"@id":"https:\/\/cosmetic-labs.com\/services\/clinical\/efficacy\/skin-comfort-testing\/inflammation-skin-immunity\/antimicrobial-peptides#service"}]
```